期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细菌耐药性的分子机制研究进展 被引量：2

Research Advance on Molecular Mechanisms of Antibiotic Resistance in Bacteria
下载PDF
导出
摘要 对细菌耐药性的产生及分子机制即固有耐药性、获得性耐药性、耐药性基因移动的方式等进行了论述,并着重分析了获得性耐药机制及耐药性基因移动的方式,对存在问题及发展前景进行了展望. This paper presents a study on the happening of bacterial resistance to antibiotics and its molecular mechanisms such as intrinsic resistance,acquired resistance, and ruouement loays of resistant genes. The acguired resistance mechanisms and the mouement ways of resistant genes were analysized in particular. The existing problems and its prospect are pointed out.
作者 杨霞 王川庆 卢中华
机构地区 河南农业大学牧医工程学院
出处 《河南农业大学学报》 CAS CSCD 北大核心 2007年第3期350-355,共6页 Journal of Henan Agricultural University
基金 河南省科技厅重点科技攻关项目(0322011000)
关键词 细菌 耐药性 抗生素 分子机制 bacteria resistance antibiotics molecular mechanisms
分类号 S852.6 [农业科学—基础兽医学]
  • 相关文献

参考文献28

  • 1翁心华.感染性疾病防治面临的挑战与机遇[J].中国实用内科杂志,2003,23(12):708-708. 被引量：7
  • 2BAMBEKE F,TULKENS P M.Macroides:pharmacokincs and pharma-codynamics[J].Int Antimicrob Agents,2001,18(1):17-19.
  • 3SHAPIRO J A.Views about evolution are evolving[J].American Society for Microbiology News,1999,5:201-207.
  • 4ROBERTS M C,CHUNG W O,ROE D.Erythromycinresistant Neisseria gonorrhoeae and oral commensal Neisseria spp.carry known rRNA.methylase genes[J].Antimicrobial Agents and Chemotherapy,1999,43:1367-1372.
  • 5AARESTRUP F M,JENSEN L B.Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides[J].Antimicrob Agents Chemother,2000,44(12):3425-3427.
  • 6LI X Z,NIKAIDO H.Efflux-mediated drug resistance in bacteria[J].Drugs,2004,64(2):159-204.
  • 7MCKEEGAN K S,BORGES M I,WALMSLEY A R.The structure and function of drug pumps:an update Trends[J].Microbiol,2003,11(1):21-29.
  • 8SAIER M H,PAULSEN I T,SLIWINSKI M K.Evolutionary origins of muhidrug and drug-specific efflux pumps in bacteria[J].The FASEB Journal,1998,12:265-274.
  • 9PAO S S,PAULSEN I T,Saler M H.Major facilitator superfamily[J].Microbiol Mol Biol Rev,1998,62:1-32.
  • 10VAN H W,KONINGS W N.The ABC family of multidrug transporters in microorganisms[J].Biochem biophs Acta,1998,1365:31-36.

二级参考文献66

  • 1[21]Takenouchi T, Sakagawa E, Sugawara M. Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones [J]. Antimicrob Agents Chemother, 1999,43(2): 406
  • 2[22]Masuda N, Sakagawa E, Ohya S. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa[J]. Antiumicrob Agents Chemother , 1995,39(3) :645
  • 3[23]Lomovskaya O, Lee A, Hoshino K, et al. Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa[J]. Antimicrob Agents Chemother,1999,43(6):1340
  • 4[24]Ziha-Zarifi Ⅰ, Llanes C, Kohler T, et al. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-oprM [J]. Antimicrob Agents Chemother, 1999,43(2):287
  • 5[25]Lomovskaya O, Warren M S, Lee A, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy[J].Antimicrob Agents Chemother, 2001,45(1):105
  • 6[1]Bush K, Jacoby G A, Medeiros A A. A functional classification scheme for β-lactanases and its correlation with molecular structure[J]. Artimicrob Agents Chemother , 1994,39(6): 1211
  • 7[2]Coulton S, Francois Ⅰ. β-Lactamases :targets for drug design [J].Prog Med Chem, 1994,31:298
  • 8[3]Nass T, Livermore D M,Nordmann P. Characterization of an LysR family potein, SemR from Serratia marcessecs S6. its effect on expression of the carbapenem-hydrolyzing β-lactamases Sme-1 and comparison of this regulator with other β-lactamases regulators[J]. Antimicrob Agents Chenother , 1995,39:629
  • 9[4]Rasmussen B A, Bush K, Keeney D, et al. Characterization of LMI-1β-lactamases, a nover class A carbapenem hydrolyzing enzyme from Enterobacter cloacae[J]. Antimicrob Agents Chemother, 1996,40:2080
  • 10[5]Yamane A, Nakano H, Asahi Y, et al. Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2Bof penicillin-resistant Streptococcus pneumoniae[J]. Antimicrob Agents Chemother , 1996,40:1257

共引文献153

同被引文献48

引证文献2

二级引证文献14

河南农业大学学报
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部