摘要
目的研究妊娠高血压疾病(hypertension disorders of pregnancy)[妊娠高血压综合征(pregnancy-induced hypertension syndrome,PIH)]患者静脉血清及脐血中可溶性黏附因子的表达。方法用酶联免疫吸附法(ELISA)进行定量检测60例妊娠高血压疾病患者(轻、中、重型各20例)及30例正常对照组产妇静脉血清及脐血中sE-选择素、血小板内皮细胞黏附因子-1(platelet endothelial cell adhesionmolecule-1,PECAM-1)的含量。结果sE-选择素、PECAM-1在妊娠高血压疾病组及对照组血清及脐血中均有表达。sE-选择素在妊娠高血压疾病各组血清中表达,与对照组血清中的比较,差异有显著意义(P<0.05);与脐血中的比较,差异无显著意义(P>0.05)。妊娠高血压疾病各组与对照组血清和脐血中的PECAM-1比较,差异无显著意义(P>0.05)。妊娠高血压疾病患者血清中sE-选择素与自身脐血中的比较,差异有显著意义(P<0.001);血清中PECAM-1与自身脐血中的比较,差异无显著意义(P>0.05)。结论sE-选择素的高表达说明,妊娠高血压疾病患者内皮细胞损伤,且sE-选择素在损伤过程中起作用。PECAM-1在妊娠高血压疾病患者发病过程中作用不明显。
Objective To investigate the expression of soluble adhesion molecules in peripheral blood and umbilical cord blood of patients with hypertension disorders of pregnancy ( pregnancy-induced hypertension syndrome, PIH). Methods Concentration of sE-selection and platelet endothelial cell adhesion molecule-1 (PECAM-1)in peripheral blood and umbilical cord blood from 60 patients with hypertension disorders of pregnancy,which were quantitatively detected by enzyme-linked immunosorbent assay(ELISA), 60 cases were divided into mild,middle and severe group included 20 patients, 30 normal pregnant womem were taken as controls. Results ①sE-selection and PECAM-1 were all expressed in both patients and controls. Concentration of sE-selection in peripheral blood of patients was higher than that of controls(P〈0.05). There was no significant difference in concentration of PECAM-1 between two groups (P〉0. 05). ②Concentration of sE-selection in patients' peripheral blood was significant higher in comparison with that in her umbilical cord blood (P 〈 0. 001). Concentration of PECAM-1 had no significant difference (P 〉 0. 05). Conclusion The high expression of sE-selection in hypertension disorders of pregnancy indicates the injury of vascular endothelium cells, sE-selection may play a role during the injury.
出处
《中华妇幼临床医学杂志(电子版)》
CAS
2007年第4期199-201,共3页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
东莞市科技局立项课题(编号:2004-87)
关键词
妊娠高血压综合征
可溶性黏附因子
SE-选择素
血小板内皮细胞黏附因子-1
脐血
hypertension disorders of pregnancy
soluble adhesion molecules
sE-selection
endothelial cell adhesion molecule-1(PECAM-1)
umbilical cord blood