血清NSE和CA153联合检测对胶质瘤的诊断意义

Combined Evalution of Serum NSE and CA153 in Diagnostic Significance of Gliomas

目的:研究血清NSE、CA153联合检测在胶质瘤中的诊断中的意义。方法:对45例胶质瘤患者及22例脑良性肿瘤患者血清NSE、CA153进行检测。结果:胶质瘤组中NSE、CA153阳性率分别为62.22%、73.33%,与脑良性肿瘤组比较均有显著差异(P<0.05),NSE、CA153在不同恶性程度胶质瘤中阳性率有显著性差异(P<0.05)。NSE+CA153联合检测在诊断脑胶质瘤中的特异性及敏感性均较单项检测高。结论:NSE、CA153联合检测对胶质瘤的早期诊断、高危人群的肿瘤筛查、病理分期及临床确诊有重要意义。

Objective： To investigate the combined evalution of serum NSE and CA153 for diagnostic significance of gliomas. Methods： The serum level of NSE and CA153 were measured in 45 patients having gliomas and 22 patients with benign tumor of brain. Results： The positive rate of serum NSE and CA153 in gliomas, were 62.22% and 73.33% respectively, and they were significantly higher than that in benign brain tumor. The positive rate of serum NSE and CA153 in gliomas of different malignant degrees was significantly different. Specificy and sensitivity of the combined evalution of were higher than that of the single index in diagnosis of Gliomas. Conclusion： Combined evalution of serum NSE and CA153 had is important significance in early diagnosis, tumor screening of high - risk group, pathologic stage and final clinical diagnosis of gliomas.