子宫内膜腺体异型增生与子宫内膜浆液性乳头状腺癌相关性研究

A Study of the Correlation between the Endometrial Glandular Dysplasia and Uterine Papillary Serous Adenocarcinoma

目的:研究子宫内膜浆液性乳头状腺癌组织和癌旁组织内子宫内膜腺体异型增生腺体在免疫表型和形态学上的特征和相关性。方法:镜下观察子宫内膜浆液性乳头状腺癌和子宫内膜样腺癌癌旁组织中具有子宫内膜腺体异型增生特征的腺体,观察其形态特征,记录其数目,统计学分析,比较其与两种类型子宫内膜癌相关性的差异;S-P法对具有子宫内膜腺体异型增生的子宫内膜浆液性乳头状腺癌和癌旁组织进行P53和Ki67免疫组织化学染色,P53染色进行半定量分析,计算Ki67指数,比较不同组织区间的差异。结果:子宫内膜腺体异型增生与子宫内膜浆液性乳头状腺癌相关,子宫内膜腺体异型增生P53免疫组织化学染色强度和Ki67指数介于子宫内膜浆液性乳头状腺癌和正常子宫内膜腺上皮之间。结论:子宫内膜腺体异型增生与子宫内膜浆液性乳头状腺癌高度相关,可能是其前驱病变。

Objective： To investigate the clinic pathological and immunophenotypic features of the endometrial glandular dysplasia （EmGD） and the correlation between EmGD and uterine papillary serous adenocarcinoma （UPSC）. Methods： Clinicopathological study was made on 18 cases of UPSC and 24 cases of uterine endometrial adenocarcinoma （UEC）. Special attention was paid to the morphologic features and numbers of EmGD in the para - cancer tissue of UPSC and UEC. The difference of the correlation between EmGD and UPSC or UEC was analyzed. Immunohistochemical staining was performed by SP method using antibodies P53 and Ki67. Semi - quantity analysis was made on the immunohistochemical staining. Results： Compared with UEC, EmGD was highly correlated with UPSC. The values of P53 immunohistochemical staining intensity and Ki67 index of EmGD were between those of UPSC and normal resting endometrial glands. Conclusion： High correlation existed between EmGD and UPSC. EmGD probably was the precursor lesion of UPSC.