期刊文献+

醛固酮对心血管系统的不良影响与治疗 被引量:4

Adverse Impact of Aldosterone on Cardiovascular System and Its Theray
下载PDF
导出
摘要 醛固酮可以引起水钠潴留,从而影响血容量和血压,进而可引起心血管系统的损害。这种反应的机制的根本是由于盐皮质激素受体(mineralocorticoid receptor,MR)的激活。在原发性醛固酮增多症及某些实验室高血压模型中MR的激活反映了醛固酮水平与盐水平的不平衡,即有自主性的醛固酮分泌;而在原发性高血压及心力衰竭中醛固酮和Na+的水平在治疗前都是正常且相互平衡的。MR阻滞剂的使用可以明确地改善心血管系统的症状和结局。 Retention of water and sodium can be induced by aldosterone, which change the blood value and blood pressure, as the result, cardiovascular system is impaired. The mechanism is that mineralocorticoid receptor is activated. In primary aldosteronism and some high blood pressure models, activated mineralocorticoid receptor reflects the disequilibrium between aldosterone and mineral, that is to say autonomic secreted aldosterone exits. However, in primary high blood pressure and heart failure, the level of aldosterone and Na^+ is equilibrium before therapy. Mineralocorticoid receptor inhibitor can improve symptom and result of cardiovascular system obviously.
出处 《华西医学》 CAS 2007年第3期551-552,共2页 West China Medical Journal
关键词 醛固酮 心血管系统 aldosterone Cardiovascular System
  • 相关文献

参考文献6

  • 1Brilla CG,Matsubara LS,Weber KT,et al.Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperal-dosteronism[J].J Mol Cell Cardiol,1993,25:563-575.
  • 2Pitt B,Zannad,Remme WL,et al.The effect of spironolactone on morbidity and mortality in patients with severe heart failure[J].N Engl J Med,1999,341:709-717.
  • 3Pitt B,Zannad,Remme WL,et al.Eplerenone,a selective aldosterone ocblker,in patients with left ventricular dysfunction after myocardial infarction[J].N Engl J Med,2003,348:1309-1321.
  • 4Krum H,Nolly H,Workman D,et al.Efficacy of eplerenone added to rinin-angiotensin blockade in hypertensice patients and white patients[J].Hypertension.2002,40(2):117-123.
  • 5Rocha R,Martin-Berger CL,Yang P,et al.Selective aldosterone blockade prevents angiotensinⅡ/salt-induced vascular inflammation in the rat heart[J].Endocrinology.2002,143:4828-4836.
  • 6Levy DG,Rocha R,Funder JW,et al.Distinguishing the antihypertensive and electrolyte effects of eplerenone[J].J Clin Endocrinol Metab,2004,89:2736-2740.

同被引文献50

引证文献4

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部