摘要
醛固酮可以引起水钠潴留,从而影响血容量和血压,进而可引起心血管系统的损害。这种反应的机制的根本是由于盐皮质激素受体(mineralocorticoid receptor,MR)的激活。在原发性醛固酮增多症及某些实验室高血压模型中MR的激活反映了醛固酮水平与盐水平的不平衡,即有自主性的醛固酮分泌;而在原发性高血压及心力衰竭中醛固酮和Na+的水平在治疗前都是正常且相互平衡的。MR阻滞剂的使用可以明确地改善心血管系统的症状和结局。
Retention of water and sodium can be induced by aldosterone, which change the blood value and blood pressure, as the result, cardiovascular system is impaired. The mechanism is that mineralocorticoid receptor is activated. In primary aldosteronism and some high blood pressure models, activated mineralocorticoid receptor reflects the disequilibrium between aldosterone and mineral, that is to say autonomic secreted aldosterone exits. However, in primary high blood pressure and heart failure, the level of aldosterone and Na^+ is equilibrium before therapy. Mineralocorticoid receptor inhibitor can improve symptom and result of cardiovascular system obviously.
出处
《华西医学》
CAS
2007年第3期551-552,共2页
West China Medical Journal
关键词
醛固酮
心血管系统
aldosterone
Cardiovascular System