河北省2004—2005年抑郁症的现况调查

The prevalence of major depression disorders in Hebei Province from 2004 to 2005

目的了解河北省抑郁症的患病率、抑郁症患者的人口学特征及社会生活功能状况。方法采用随机抽样方法对河北省≥18岁人群进行调查,共24 000人。以改编的一般健康问卷12项(GHQ-12)为筛选工具,以美国精神障碍诊断与统计手册第4版轴Ⅰ障碍定式临床检查患者版为诊断工具。采用功能大体评定量表(GAF)评价功能状况。结果 (1)抑郁症时点患病率为27.01‰[399例;95%可信区间(CI)=24.80‰～29.22‰],终生患病率为47.47‰(608例;95%CI=44.58‰～50.37‰)。(2)时点患病率:城市[20.98‰(40例)]低于农村[27.88‰(359例);u=4.02;P<0.01];女性[31.53‰(248例)]高于男性[22.48‰(151例);u=2.05;P<0.05]。≥40岁者患病率高(30.51%-44.19%)。(3)Logistic 回归分析:危险因素有女性、年龄40～70岁、农民、无业和失业、学生和家庭妇女、年家庭总收入0～5000元等。(4)反复发作抑郁症占29.11%;严重程度以中度(39.6%)和重度(53.9%)多见,社会和生活功能受损明显[GAF 评分为(58.95±14.86)分]。结论河北省抑郁症的患病率较高,严重影响患者社会生活功能。

Objective This survey was to know about the prevalence, demology characteristics and function status of the major depression disorders （MDD） in Hebei Province. Methods A total of 24 000 people aged 18 or over was sampled randomly from Hebei. The revised edition of the General Health Questionnaire （GHQ-12） was used for screening, and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders-Patient Edition （SCID-I/P） was used to make a diagnosis of MDD. Results The current prevalence of major depression disorders was 27. 01%e （ 95% CI = 24. 80%e - 29. 22%o） , and lifetime prevalence was 47.47%0 （ 95% CI =44.58% - 50. 37%o）. The current prevalence was significantly higher in rural population than that in townsmen （27. 88%o vs. 20. 98%o; u =4. 02; P 〈 0. 01 ）, so were in female than in male （31.53%o vs. 22.48%o ; u = 2. 05 ; P 〈 0. 05 ）, in population aged 40 - 70 year old than that in younger age population. Logistic regression analysis showed that the female, aged 40 - 70 years, peasant, jobless/unemployment, students/family women and family average annual income below 5000 RMB were associated higher prevalence of MDD. About one thirds of patients were having recrudescent major depression disorders, with moderate to severe symptom, and impairments in social and personal functions. Conclusion Major depression disorder is a common mental disorder in the population in Hebei Province.