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针对宿主细胞靶位抗HCV策略研究进展 被引量：1

Progress in the anti-hepatitis C virus strategies targeting on host cells
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摘要 慢性HCV(CHC)感染是严重危害人类健康疾病之一.现阶段HCV治疗策略疗效有限,有必要寻找更新更好的抗HCV策略.宿主细胞因素为HCV感染、复制和/或致病所必需,因此可能成为潜在的治疗靶位.最引人注意的细胞因素包括,介导病毒入胞细胞受体、促进病毒复制、组装等细胞因素和细胞内脂质生物合成途径、氧化应激压力及内源性免疫反应等.目前的关键问题是从药理学角度调控这些细胞靶位,减少副反应,从而利于慢性HCV感染治疗.本文主要就近几年的相关研究进展作一简要综述. Chronic hepatitis C virus （HCV） infection is one of the serious diseases endangered people＇s health. The current therapy for HCV infection has limited efficacy, and new and more effective therapies are pressingly needed. Host cell factors that are required for HCV infection, replication and/or pathogenesis represent potential therapeutic targets. The most interesting cellular factors are cellular receptors that mediate HCV entry, factors that facilitate HCV replication and assembly, and intracellular pathways involving lipid biosynthesis, oxidative stress and innate immune response. The key issue now is to manipulate such cellular targets pharmacologically for the treatment of chronic HCV infection, without being limited by side effects. This paper mainly related to the nearest years of research progress for a brief overview.
作者 梁雪松 安艳
机构地区 中国人民解放军第二军医大学长海医院感染科 山东省医学科学院放射医学研究所
出处 《世界华人消化杂志》 CAS 北大核心 2007年第15期1754-1758,共5页 World Chinese Journal of Digestology
关键词 慢性感染 丙型肝炎病毒 宿主细胞因素 治疗 Chronic infection Hepatitis C virus Cellular factors Therapy
分类号 R512.63 [医药卫生—内科学]
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参考文献27

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同被引文献19

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世界华人消化杂志
2007年 第15期

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