青海地区近十年胃癌构成分析

An analysis on the proportion of gastric cancer in Qinghai region from 1994 to 2003

目的：探讨近十年来胃癌临床病理特点的发展趋势．方法：以我院1994-2003年间经胃镜检查和病理证实的胃癌1765例为研究对象，分成1994—1998和1999—2003前后两组．探讨性别、年龄、部位、组织学类别的差异．结果：两组资料中男女之比较为接近分别为1组3．33：1，2组3．29：1．男性构成比均明显高于女性（P〈0．05），但两组间差异无显著性．1765例患者40岁以下者795例（12．86％1，40—60岁者227例f45．04％），60岁以上者227例（42．10％），两组内年龄在40岁以上的胃癌患者构成比均较高．与2组相比，1组40—60岁患者构成比高于2组（x^2=6．116，P=0．013），而60岁以上患者比例低于2组（x^2=4．983，P=0．026）．两组患者发病部位均以胃体、胃窦及贲门处为最常见．相对于1组，2组胃癌发生于胃底处患者比例增多（x^2=6．116，P=0．01），而发生于幽门处者比例减少（x^2=6．116，P=0．007）．两组胃癌患者常见组织类型都为低分化腺癌及中分化腺癌．结论：胃癌患者发病年龄上升，发生部位有向近端上移趋势．

AIM： To study the clinicopathologic variation trend of gastric cancer during the past ten years. METHODS： A total of 1765 gastric cancer patients diagnosed with endoscopy and pathologic examination were included in this study. The cases were divided into 2 groups. Group A comprised patients during 1994 to 1998, while group B consisted of ones during 1999 to 2003. Statistical comparison analyses on the age, sex of patients, distribution and histological type of gastric cancer were performed. RESULTS： The male to female ratio was 3.33 ： 1 in group A, and 3.29 ： 1 in group B. The proportion of the male was evidently higher than that of the female in both groups （P 〈 0.05）. The proportion of patients with different ages was 12.86% （〈 40 years old）, 45.04% （40-60 years old） and 42.10% （〉 60 years old）, respectively. The patients over 40 years old showed a higher ratio than the others. In comparison with group B, the proportion of patients aged 40 to 60 years in group A was increased （x^2 = 6.116, P =- 0.013）, while that of patients over 60 years old was decreased （x^2 = 4.983, P = 0.026）. In both groups, gastric carcinoma occurred mainly at gastric body, antrum and cardia part. As compared with group A, there was an increase in the proportion of gastric cancer at fundus （x^2 = 6.116, P = 0.01） while a corresponding decrease in the proportion of pyloric carcinoma （x^2 = 6.116, P = 0.007） in group B. The familiar tissue types in both groups were lowly- and moderately-differentiated adenocarcinoma. CONCLUSION： The age of gastric cancer patients is going up, and there is a trend towards proximal stomach in the location of gastric cancer.