高血压病中医证型与血脂紊乱的相关性

Correlation between Chinese Medical Pattern of Hypertension and Blood Fat Disorder

目的探讨高血压病不同中医证型与血脂紊乱的相关性以探索高血压病中医辨证的客观化指标。方法收集111例住院高血压病患者,设计调查表,准确填写临床资料,并以20名健康人作为对照组。由两名中级以上职称的医师根据有关高血压病的中医证候标准进行辨证,得出辨证结论。对试验组不同证型之间及试验组与对照组进行比较。结果试验组与对照组比较,存在明显的血脂紊乱,尤以胆固醇(TC)升高和高密度脂蛋白胆固醇(HDL-C)降低最明显(P<0.05或P<0.01)。在试验组各证型的比较中,痰湿壅盛型HDL-C降低最明显。阴阳两虚型低密度脂蛋白胆固醇(LDL-C)升高明显。结论血清甘油三酯(TG)升高和HDL-C降低可以作为痰湿壅盛证辨证的客观化指标;LDL-C升高可以作为阴阳两虚证辨证的客观化指标。

Objective To find objective indexes for Chinese medical pattern identification of hypertension by researching the correlation between different Chinese medical patterns of hypertension and blood fat disorder. Methods Clinical data of 111 in-hospital hy- pertension patients were collected according to questionaire designed and 20 healthy persons were selected as control group. Chinese medical pattern identification was conducted by 2 experienced doctors according to Chinese medical pattern standard of hypertension. Comparison was done among different Chinese medical patterns of trial group and between trial and control groups. Results As compared with control group, the level of total cholesterol（TC） increased but high density lipoprotein cholesterol （HDL-C） decreased obviously in trial group （P〈0. 05 or P〈0.01）. As compared with other patterns in trial group, HDL-C of phlegm-damp congestion pattern decreased and low density lipoprotein cholesterol （LDL-C） of yin-yang deficiency pattern increased obviously. Conclusion The increase of triglyeride and decrease of HDL-C can be applied as objective indexes for phlegm-damp congestion pattern identification, while the increase of LDL-C for yin-yang deficiency pattern identification.