2型糖尿病并发周围神经病变与血清抵抗素水平的关系

The relationship between resistin and the peripheral neuropathy in type 2 diabetes

目的探讨血清抵抗素水平与2型糖尿病(T_2DM)并周围神经病变(PN)的关系。方法采用酶联免疫法测定下列2组的血清抵抗素水平。将96例 T_2DM 患者分为2组,DM 并发 PN组(DM+PN,n=52),单纯 DM 组(DM,n=44),对照组(NC,n=34)。结果 DM+PN 及 DM 组血清抵抗素水平均明显高于 NC 组(P<0.05);二者相比,DM+PN 组血清抵抗素水平较 DM 组明显升高(P<0.05)。相关分析发现,血清抵抗素浓度与空腹血清胰岛素(FINS)、空腹血清内皮素(ET)、收缩压(SBP)、舒张压(DBP)及 HOMA 胰岛素抵抗指数(HOMA-IR)呈显著正相关(均 P<0.05),与HOMA-β细胞功能指数(HOMA-β)及空腹血清一氧化氮(NO)显著负相关(P<0.05)。结论 DM+PN 组血清抵抗素水平显著高于 DM 组,高抵抗素血症与 ET、NO 的相关性提示,抵抗素可能在2型糖尿病周围神经病变(PN)的发病中起一定作用。

Objective To investigate the relationship between the serum resistin concentration and type 2 DM with peripheral neuropathy. Methods Ninety-six patients of type 2 diabetes pmellitus （ DM ） among which 52 were with peripheral neuropathy （ DM ＋ PN ） and 34 healthy persons undergoing routine physical examination as controls were studied. Body weight, waist circumference, blood pressure, body mass index （BMI）, fasting insulin （FINS）, homeostasis model assessment of insulin resistance （HOMA-IR）, and beta-cell action measured by the homeostasis model assessment （ HOMA-β ） , and blood lipids were measured. ELISA was used to detec the srerum resistin, epithelin （ET）, and nitrogen oxide （NO）. Results The srum resistin level of the DM ＋ PN patients was （ 26± 9） ng/ml, significantly higher than that of the DM patients [ （ 20 ± 6 ） ng/ml, P 〈 0.05 ]. Th serum resistin level was positvely correlated with FINS, Homa-IR, systolic blood pressure, diastolic blood pressure, and ET（ all P 〈 0.05 ） and significantly negatively correlated with HOMA-β and NO （both P 〈 0.05 ）. Conclusion Resistin may play a role in the pathogenesis of type 2 DM and diabetic peripheral neuropathy.