肝胆转运系统在肝移植术后胆汁排泌功能障碍中的作用
摘要
肝移植是治疗终末期肝胆疾病的有效手段，但术后淤胆和胆管并发症仍是棘手问题。肝胆转运系统在胆盐、磷脂和胆固醇等分泌和排出中起关键作用，但肝移植中的缺血冷保存及免疫反应等不可避免地造成肝细胞、胆管细胞及其转运蛋白的功能障碍，影响术后的胆汁排泌。临床上可因胆汁中脂质和胆盐比例失衡，使疏水性胆盐损伤细胞膜和线粒体，造成淤胆、胆泥和结石形成、
出处
《中华外科杂志》
CAS
CSCD
北大核心
2007年第15期1031-1033,共3页
Chinese Journal of Surgery
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