1[1]Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phosphotase gene mutated in humain brain,breast and prostate cancer[J].Science,1997,275:1943-1947.
2[2]Steck PA,Pershouse MA,Jzsser,et al.Identification of a candidate tumor suppressor gene,MMAC1,at chromosome 10q23.3 that is mutated in multiple advanced cancersrs[J].Nat Genet,1997,15:356-363.
3[3]Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor locus is a novel protein tyrosine phosphostase regulated by transforming growth factor[J].Cancer Res,1997,57:2124-2129.
4[4]Myers MP,Stolarov J P,Eng C,et al.PTEN,the tumor suppressor from human chromosome 10q23,is a dual-specificity phosphatase[J].Proc Natl Acad Sci USA,1997,94:9052-9057.
5[5]Maehama T,Dioxn JE.The tumor suppressor,PTEN/MMACl,dephosphorylates the lipid second messenger,phosphatidylinositol 3,4,5-trisphosphate[J].J Biol Chem,1998,273:13375-13378.
6[6]Steck PA,Pershouse MA,Jasser SA,et al.Identification of a candidate tumour suppressor gene,MMACl,at chromosome 10q23.3 that is mutated in multiple advanced cancers[J].Nat Genet,1997,15:356-362.
7[7]Farrow B,Evers BM.Activation of PPARγ increases PTEN expression in pancreatic cancer cells[J].Biochem Biophys Res Commun,2003,301:50-53.
8[8]Sukmi KP,Yoon IL,Young IL.PTEN modulates insulin-like growth factor Ⅱ(IGF-Ⅱ)-mediated signaling;the protein phosphatase activity of PTEN down-regulates IGF-Ⅱ expression in hepatoma cells[J].FEBS Letters,2003,545:203-208.
9[9]Weng LP,Brown JL,Eng C.PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model[J].Hum Mol Genet,2001,10:599-604.
10[10]Weng LP,Smith WM,Brown JL,Eng C,et al.PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model[J].Hum Mol Genet,2001,10:605-616.
二级参考文献25
1Chatterjees. Role of oxidized human plasma LDL in atherosclerosis: effect on smooth muscle cell proliferation. Mol Cell Biochem,1992,111: 142-147
2Cohen P. Protein kinases and protein phosphatase: the Yin and Yang of protein phosphorylation and signaling. Cell,1995,80: 255-236
4Zhong H,Chiles K,Feldser D,et al. Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor PI3K/PTEN/AKT/FRAP pathway in human prostate cancer cell: implication for tumor angiogenesis and therapeutics. Cancer Res,2000,60: 1 541-545
5Martens JS,Reiner NE,Herrera VP,et al. Phosphatidylinosital 3-kinase is involved in the induction of macrophage growth by oxidized low density. Lipoprotein,1998,1 273: 4 915-920
6Han HY,Kato H,kato S,et al. Functional evaluation of PTEN missense mutation using in vitro phosphoinositide phosphatase assay. Cancer Res,2000,60: 3 147-151
7Tamura M,Gu J,Matsumoto K,et al. Inhibition of cell migration,spreading,and focal adhesions by tumor suppressor PTEN. Science,1998,280: 1 614-617
8Hanks SK,Polte TR. Signaling through focal adhesion kinase. Biol Essay,1997,19: 137-145
9Ozes ON,Akca H,Mayo LD,et al. A PI3K/Akt/mTOR pathway mediates and PTEN antagonize tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. PNAS,2001,98: 4 640-645
10Jiang Y,Broach JR. Tor proteins and protein phosphatase2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J,1999,18: 2 782-792
7Morisco C, Seta K, Hardt SE, et al. Glycogen synthase kinase 3 beta regulates GATA4 in cardiac myocytes[ J]. J Biol Chem, 2001,276(30) :28586 -28597.
8Doble BW, Woodgett JR. GSK - 3 : tricks of the trade for a multi - tasking kinase [ J ]. J Cell Sci, 2003, 116 ( Pt7 ) : 1175 - 1186.
9Sugden PH, Fuller SJ, Weiss SC, et al. Glycogen synthase kinase 3 ( GSK3 ) in the heart : a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis[J]. Br J Pharmacol, 2008, 153 (Suppl 1 ) : S137 - S153.
10van de Schans VA, van den Borne SW, Strzelecka AE, et al. Interruption of Wut signaling attenuates the onset of pressure overload - induced cardiac hypertrophy [ J ]. Hypertension, 2007, 49 (3) :473 - 480.
