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基质细胞衍生因子对骨髓干细胞迁移分化的影响 被引量：1

Effect of stromai cell dirived factor-1 on bone marrow stem cells migration and differentiation
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摘要 骨髓干细胞具有很强的可塑性，可向多种组织细胞横向分化，是细胞移植的最好种子之一。体内外许多试验证实，某些细胞因子可以影响移植细胞的微环境，进而影响骨髓干细胞的动员、迁移及分化。基质细胞衍生因子属于趋化因子中CXC亚家族，特异性引起表达CXCR4的骨髓干细胞趋化反应，就基质细胞衍生因子对骨髓干细胞动员、迁移及分化的影响作一综述。 The bone marrow stem cells（BMCs） are very capable and has the abillity of transversal differentiation into many kinds of tissue cells. At present, they are one of the best choice for cell transplantation. Many in vivo and vitro confirmed that some cytokines can influence the microenvironment of transplanted ceils. Furthermore, they will influence the mobilization ,migration, and differentiation of BMCs. Stromal cell derived factor-1 （SDF-1） is a CXC type chemokine that specifically induces chemotactic reaction of CXCR4-expressing BMCs. This article reviewed the effects of SDF-1 in the mobilization, migration, and differentiation of BMCs.
作者 祁金锋 韩明子
机构地区 哈尔滨医科大学第二附属医院消化内科
出处 《国际生物医学工程杂志》 CAS 2007年第3期142-144,共3页 International Journal of Biomedical Engineering
基金 黑龙江省自然科学基金资助项目（D200536）
关键词 骨髓干细胞 基质细胞衍生因子 迁移 bone marrow stem cell stromal cell derived factor-1 migration
分类号 R3 [医药卫生—基础医学]
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参考文献25

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同被引文献19

  • 1邓均,艾国平,周桃莉,王军平,徐辉,邹仲敏,董世武,郝磊,冉新泽,粟永萍.G-CSF动员循环间充质干细胞及其对小鼠颅脑损伤修复的可行性分析[J].第三军医大学学报,2007,29(12):1131-1134. 被引量：10
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国际生物医学工程杂志
2007年 第3期

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