血清泌乳素水平与帕金森病痴呆的相关性研究

A study of relationship between blood serum prolactin level and parkinson's disease with dementia

目的探讨帕金森病痴呆(PDD)患者及帕金森病(PD)与血清泌乳素(PRL)的关系。方法测定30例在我院门诊体检中心进行体检的正常健康老人(正常对照组),PD非痴呆患者(PD组)30例及帕金森病痴呆(PDD组)患者30例的血清PRL水平。并采用简明智能状况评价量表(MMSE)把PD患者分别划为痴呆组和非痴呆组。分别比较各组的血清PRL水平。结果PD非痴呆组者的血清PRL平均水平为6.49±67μg/L,低于正常对照组11.77±2.38μg/L;PDD组平均PRL水平为1.94±0.83μg/L,明显低于PD非痴呆组6.49±1.67μg/L。结论PDD患者的血清PRL水平是降低的。PDD患者的痴呆表现越重,血清PRL水平越低,二者呈高度相关。

Objective To investigate the relationship of blood serum prolaetin （PRL） level between parkinson＇s disease with dementia （PDD） patients and parkinson＇s disease （PD） patients. Methods We detected the blood serum PRL level of 30 normal healthy old people （normal control group） who preceded the physical examination in the physical examination centre of our hospital,and 30 parkinson＇s disease patients （PD group） and 30 parkinson＇s disease with dementia （PDD group） patients. Mini-mental state examination （MMSE） was used to divide the PD patients into the dementia group and non-dementia group. We compared the serum PRL level of each group respectively. Results Average serum PRL level of the parkinson＇s disease group was 6.49± 1.67μg/L, which was lower than normal control group 11.77±2.38μg/L;Average serum PRL level of the PDD group was 1.94±0.83μg/L,obviously lower than PD group 6.49± 1.67μg/L. Conclusion The serum PRL level in PDD patients is decreased. The more severe dementia symptom in PDD patients is,the lower serum PRL level is,and they have high correlation.