苯甲酸利扎曲普坦口腔速崩片的制备

Preparation of Rizatriptan benzoate fast disintegrating oral tablet

目的制备苯甲酸利扎曲普坦口腔速崩片。方法选用微晶纤维素(MCC)和低取代羟丙基纤维素(LHPC)作为崩解剂,通过粉末直接压片工艺制备口腔速崩片。考察速崩片的性质。结果当MCC/LHPC的比例为9:1时,其体外崩解时间在20 s以内,体内崩解时间在30 s以内。结论所制片剂口感良好,优化的工艺可以工业化生产。

OBJECTIVE To prepare a Rizatriptan benzoate fast disintegrating oral tablet. METHODS Microcrystalline cellulose and low substituted hydroxypropylcellulose were used as disintegrants, fast disintegrating tablets could be prepared by direct powder compression method. The properties of these tablets, such as hardness, and disintegration time were investigated to elucidate the disintegration characteristics of these tablets. RESULTS When the MCC/LHPC ratio was 9 ： 1 ,the disintegration time was within 20 s in vitro test and was within 30 s in mouth, respectively. CONCLUSIONS The selected formulation and preparation technique are good and can contribute to the development of the product.