复发性上皮性卵巢癌41例临床分析

Clinical analysis of 41 cases of recurrent epithelial ovarian cancer

目的:探讨复发性上皮性卵巢癌的综合治疗方法、再次肿瘤细胞减灭术的临床价值及影响再次肿瘤细胞减灭术治疗效果的因素。方法:回顾性分析41例复发性上皮性卵巢癌的临床资料。结果;复发后行再次肿瘤细胞减灭术联合术后化疗的患者和单纯化疗的患者比较复发后生存时间明显延长(P<0.05);复发后进行再次肿瘤细胞减灭术联合术后化疗的22例患者中初次治疗后的临床缓解时间(DFI)≤12个月的患者复发后中位生存时间较DFI>12个月的患者明显缩短(P<0.01);再次肿瘤细胞减灭术基本切净或残余灶≤2cm的患者和残余灶>2cm的患者比较,复发后中位生存时间明显延长(P<0.05);再次术后化疗疗程数>3次的患者和≤3次的患者比较,复发后中位生存时间明显延长(P<0.01)。结论:在严格选取手术适应症的前提下,再次肿瘤细胞减灭术辅以术后规律、足疗程的化疗可以延长复发患者的生存时间。

Objective： To investigate the treatment about the recurrent epithelial ovarian cancer, the clinic value of recytoreductive surgery and the factors relative to the therapeutic efficacy of recytoreductive surgery. Methods： Forty -one patients＇clinic records were analyzed retrospectively. Results： The patients who received recytoreductive surgery followed chemotherapy , the median survival time after recurrence was longer than the median survival time of patients who received chemotherapy only （P 〈0. 05） ; The median survival time of patients whose DFI was less than 12 months was significant less than that of patients whose DFI was more than 12 months （P 〈0. 01 ） ; The median survival time of patients without or less than 2cm residual lesion after recytorecluctive surgery was significant longer than who were more than 2cm residual lesion （ P 〈0. 05 ） ; The median survival time of patients who had more than three times of chemotherapy after recytoreductive surgery was significant longer than who had less than three times of chemotherapy （P 〈0. 01 ） . Conclusion： The recytoreductive surgery followed salvage chemotherapy make benefit to the selected recurrent patients.