CD9蛋白在滋养细胞中的表达及其意义

The expression of CD9 in gestational trophoblastic disease

目的:探讨妊娠滋养细胞疾病中CD9的表达及临床意义。方法:应用免疫组化S-P法,检测CD9在正常绒毛及妊娠滋养细胞疾病中的表达。结果:正常绒毛组织及葡萄胎组织中CD9阳性表达率明显高于侵蚀性葡萄胎及绒癌组织,其差异有显著性。结论:CD9蛋白在滋养细胞的浸润转移中起重要调控作用。

Objective： To investigate the expression of CD9 protein in gestational trophoblastic disease and its clinical significance. Methods： Immunohistochemical method S - P was used to examine the expression of CD9 protein in paraffin - embedded specimensof gestational trophoblastic disease. Results： The expression of CD9 protein were higher in chorion villi and hydatidiform mole than in invasive mole eh disease. Conclusion： Loss of CD9 protein expression may be associated with invasion and metastases oftrophoblastic