中西结合治疗肝硬化腹水并低蛋白血症临床研究

Clinical Efficacy of Chinese Traditional Medicine Combined Western Medicine in the Treatment of Cirrhosis with Ascites and Hypoalbuminemia

目的探讨中西医结合对肝硬化腹水并低蛋白血症的治疗效果。方法治疗组用中西医结合疗法,采用加味中满分消饮配合西医常规保肝、利尿、补充白蛋白以及纠正电解质紊乱等对症支持治疗;对照组采用西医治疗。结果治疗4周后,治疗组治愈率为43.75%,总有效率为87.50%,对照组治愈率为30.00%,总有效率为80.00%,2组疗效对比差异有显著性(P<0.01);治疗组再次住院率明显低于对照组(P<0.05);治疗组治疗前后比较,白蛋白显著升高(P<0.05),球蛋白显著降低(P<0.05),白蛋白/球蛋白显著升高(P<0.05),而对照组治疗前后血清蛋白无显著差异(P>0.05);2组肝功能比较,对照组明显下降(P<0.05～0.01)。结论中西医结合治疗组疗效明显优于西医对照组。

Objective To explore the clinical efficacy of Chinese traditional medicine combined with western medicine in the treatment of cirrhosis with ascites and hypoalbuminemia. Methods The trial group was treated with Chinese traditional medicine （modified decoction for Zhongman Fenxiao） combined with western medicine （drugs for protecting liver, diuretis, etc.）. The control group was simply treated with Western medicine. Results After 4 weeks of treatment, the cure rate of the trial group was 43.75% and the total effective rate was 87.50%, significantly higher than that of the control group with 30.00% and 80.00%, respectively （P〈0.01）. The re-hospitalized rate of the trial group was significantly lower than that of the control group （P〈0.05）. In the trial group, ALB level was significantly higher after treatment than before （P 〈0.05）, GLB level was significantly lower after treatment than the before （P 〈0.05）, and the ratio of A/G was significantly higher after treatment than before （P〈0.05）. But in the control group, the serum protein had no such changes （P〉0.05）. The liver function in the control group was greatly decreased than that in the trial group （P〈0.05-0.01）. Conclusion Chinese traditional medicine combined with western medicine is much better than simply using Western medicine in the treatment of cirrhosis with ascites and hypoalbuminemia.