活血清肺饮对肺源性心脏病急性发作期RVPEP/AT、HO-1/CO体系的影响

Effect of Huoxue Qingfeiyin on RVPEP/AT and HO-1/CO of Acute Stage of Pneumocardial Disease

目的观察活血清肺饮结合西医常规疗法对肺源性心脏病急性发作患者右室射血前期时间/肺动脉血流加速时间(RVPEP/AT)、血红素氧合酶/一氧化碳(HO-1/CO)体系的影响。方法将40例肺源性心脏病患者随机分成2组,对照组20例采取常规西医处理,治疗组20例在对照组基础上加用活血清肺饮,观察临床疗效和血气分析、RVPEP/AT、血浆CO含量。结果对照组显效率35%,总有效率75.5%;治疗组显效率65%,总有效率85%。2组显效率比较,P<0.01;总有效率比较,P>0.05。2组实验室检查组内前后对照,P<0.01;组间前后差值比较,P<0.05～0.01。PaO2与RVPEP/AT、血浆CO呈负相关,而RVPEP/AT、血浆CO、PaCO2则彼此呈正相关。结论西医综合处理加用活血清肺饮对肺源性心脏病急性发作有治疗作用,且能改善血气分析、RVPEP/AT、血浆CO含量;HO-1/CO体系在肺源性心脏病急性发作及缓解过程中起重要作用。

Objectives To observe the curative effect of routine modem treatment and Huoxue Qingfeiyin （HXQFY） on pneumocardial disease, and the contribution of RVPEP/AT, the system of heine oxygenase/ carbon monoxide （HO-1/CO）. Methods 40 patients with pneumocardial disease were randomly divided into 2 groups, routine modem medicine managements for the control group （20 patients）, the same managements and additional HXQFY for the treatment group （20 patients）. The therapeutic effects, RVPEP/AT, the plasma content of carbon monoxide were observed. Results The total effective rate was 85% in the treatment group, in contrast, it was 75.5% in the control group. There was not difference between the two groups in the total effective rate （P〉0.05）, a extreme significantly difference in the laboratory examination results in each group between before and after treatment （P〈0.01）. Obviously difference was displayed between the equation of indexes before and after treatment of the two groups （P〈0.05-0.01）. PaO2 acts as an negative correlation with RVPEP/AT and CO, while RVPEP/AT, CO and PaCO2 act as positive correlation with each other. Conclusion The treatments of HXQFY which based on routine modem medicine got manifest therapeutical effects on penumocardial disease, and improved blood gas analysis, RVPEP/AT, the plasma content of carbon monoxide. HO-1/CO plays an important role from the acute episode to anesis of penumocardial disease.