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灵菌红素的研究进展 被引量：29

Progress on Prodigiosin
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摘要 灵菌红素是一类含甲氧基吡咯骨架结构的天然色素,是一些放线菌、沙雷菌及其他细菌的次级代谢产物,具有免疫抑制、抗细菌、抗真菌和抗疟疾等多种生物活性。最近研究表明灵菌红素有很强的抗肿瘤及免疫抑制活性,因而成为研究热点。现对灵菌红素的结构、生物活性、生产现状及发展趋势作一综述。 Prodigiosin is a secondary metabolite with a methoxypyrrole ring produced by some Serratia sp., actinomycetes and a few other bacteria. Prodigiosin has several biological activities such as immunosuppressive activity, antibacterial, antimycotic and antimalarial activities, etc. Recently, lots of researches reveal that prodigiosin has strong anticancer and irnmunosuppressive activities, and research on prodigiosin draws increasing attention. A description on the structure, bioactivity, production status and development trend of prodigiosin is introduced in this paper.
作者 刘同军 杨海龙 唐华
机构地区 温州大学生命与环境科学学院
出处 《食品与药品》 CAS 2007年第08A期47-51,共5页 Food and Drug
基金 温州市科技计划项目(S2006004)
关键词 灵菌红素 抗癌作用 免疫抑制 综述 prodigiosin anticancer activities immunosuppression review
分类号 Q93 [生物学—微生物学]
  • 相关文献

参考文献35

  • 1Shieh W Y,Chen Y W,Chaw S M,et al.A red,facultatively anaerobic,marine bacterium isolated from sea water[J].Int J Syst Evol Microbiol,2003,53:479-484.
  • 2Pandey R,Chander R,Sainis K B.A novel prodigiosin-like immunosuppressant from an alkalophilic Micrococcus sp.[J].Int Immunopharmacol,2003,3(2):159-167.
  • 3袁保红,杜青平,蔡创华,周世宁.海洋细菌Pseudomonas sp.色素的提取及稳定性的研究[J].海洋通报,2005,24(6):92-96. 被引量：20
  • 4Someya N,Nakajima M,Hamamoto H,et al.Effects of light conditions on prodigiosin stability in the biocontrol bacterium Serratia marcescens strain B2[J].J Gen Plant Pathol,2004,70:367-370.
  • 5Montaner B,Perez T R.The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK[J].Toxicol Lett,2002,129:93-98.
  • 6Songia S,Mortellaro A,Tavema S,et al.Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes:retinoblastoma protein,cyclin-dependent kinase-2,and cyclin-dependent kinase-4 as molecular targets[J].J Immunol,1997,158(8):3987-3995.
  • 7Yamamoto D,Uemura Y,Tanaka K,et al.Cycloprodigiosin hydrochloride H+/Cl-symporter induces apoptosis and differentiation in HL-60 cells[J].Int J Cancer,2000,88(1):121-128.
  • 8Castillo-Avila W,Abal M,Robine S,et al.Non-apoptotic concentrations of prodigiosin (H^+/Cl^- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells[J].Life Sci,2005,78:121-127.
  • 9Melvin M S,Calcutt M W,Noftle R E,et al.Influence of the A-Ring on the redox and nuclease properties of the prodigiosins:importance of the Bipyrrole moiety in oxidative DNA cleavage[J].Chem Res Toxicol,2002,15:742-748.
  • 10Subramanian M,Chander R,Chattopadhyay S.A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties[J].Bio Med Chem,2006,14:2480-2486.

二级参考文献16

  • 1曾春民,林国强,沈鹤琴,张穗.大亚湾细菌 Pseudomonas sp.发酵产物化学成分研究[J].中国海洋药物,1996,15(2):5-7. 被引量：13
  • 2LIN Y C, SHAO Z Y, JIANG G C, et al. Penieillazine, a unique quinolone derivative with 4H-5,6-dihydro- 1,2-oxazine ring system from the marine fungus Penicillium sp. ( strain #386) from the South China Sea[J]. Tetrahedron, 2000, 56:9607-9609.
  • 3WASSERMAN H H, McKEON J E, SMITH L A, et al.Studies on prodigiosin and the bipyprole precursor [ J ].Tetrahedron, 1966, 31(Suppl.8) :647 - 662.
  • 4BOGER D L, PATEL M. Total Synthesis of prodigiosin,prodigiosene and desmethoxyprodigiosin: Diels-Alder reactions of heterocyclic azadienes and development of an effective paladium ( Ⅱ )-promoted 2, 2'-blopyrrole coupling procedure[J]. J Org Chem, 1988, 53(7) : 1405- 1415.
  • 5BOGER D L, PATEL M. Total synthesis of prodigiosin[ J ].Tetrahedron Letters, 1987, 28(22):2499- 2502.
  • 6LIN Y C, LI H J, ZHOU S N, et al. A novel γ-1actone,eutypoid-A and other metabolites fiom marine fungus Eutypa sp.( # 424) from the south China sea[J]. Indian J Chemistry, Section B,2002,41(7):1542- 1544.
  • 7LIN Y C, WU X Y, FENG S, et al. A novel N-cinnamoylcyclopeptide containing an allenic ether from the fungus Xylaria sp.(strain #2508) from the South China Sea[J]. Tetrahedron Lett, 2001, 42:449-451.
  • 8LIN Y C, WU X Y, FENG S, et al. Five unique compounds: Xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast[ J]. J Org Chem, 2001,66:6252- 6256.
  • 9Bennett J W, Bentley R. Seeing Red:the story of prodigiosin [J]. Adv.Appl. Microbiol, 2000, 47: 1-32.
  • 10Diaz-Ruiz, Montaner B,Perez-Tomas. Prodigiosin Induces Cell Death and Morphological Changes Indicativeof Apoptosis In Gastri cancer Cell Line HGT-1 [J]. Histol. Histophatol. 2001, 16(4): 415-421.

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食品与药品
2007年 第08A期

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