含镁极化液治疗急性心肌梗死的临床疗效

Beneficial effects of magnesium in combination with glucose,insulin and potassium in the treatment of acute myocardial infarction

目的观察含镁极化液(GIK,抗心梗辅助药)治疗急性心肌梗死的疗效。方法将病人62例随机分成2组,其中治疗组30例,对照组32例。治疗组入院后8h内,开始静滴GIK,每日1次,共14d;以未用含镁GIK为对照组。观察2组急性心肌梗死发生后恶性心律失常、心力衰竭的发生率以及1个月内死亡率。结果治疗组和对照组中恶性心律失常发生率分别为16.67%和46.88%(P<0.05);心力衰竭发生率分别为13.00%和31.25%(P<0.05);1个月内死亡率分别为6.67%和18.75%(P>0.05),其主要死亡原因为恶性室性心动过速和心衰。结论含镁GIK对急性心肌梗死发生后的恶性室性心律失常和心力衰竭的发生以及降低急性心肌梗死发生后的近期死亡率具有明显的疗效。

Objective To investigate the efficacy of magnesium in combination with glucose - insulin - potassium （ Mg - GIK） in the treatment of arrhythmia, heart failure and mortality in acute myocardial infarction （AMI）. Methods Sixty - two patients randomly assigned to control and trial group, 32 patients received no Mg - GIK （control） whereas 30 patients received Mg -GIK intravenously （trial）. Regular insulin 10 u with 10% potassium chloride 10 mL, 25% magnesium sulfate 10 mL, and 10% glucose 500 mL, administered intraveneously after patients hospital- ized for 14 days continuously. Results The incidence of arrhythmia rate in trial and control groups were 16.67% and 46.88% （P 〈0.05）, respectively. The heart failure rate in trial and control group were 13.00% and 31.25 % （ P 〈 0.05 ）, respectively. The mortality rate in hospital stay in trial and control group were 6.67% and 18.75% （P 〉 0.05）, respectively. The main cause of death was fatal arrhythmia and heart failure after AMI. Conclusion The results suggest that Mg - GIK therapy has beneficial effects on the treatment of AMI. Mg - GIK therapy can reduce incidence of arrhythmia rate, heart failure rate, and mortality rate in one month after AMI.