NONMEM法分析丙泊酚靶控输注在老年手术患者的群体药效学

Pharmacodynamics of propofol administered by target controlled infusion in Chinese elderly operation patients by NONMEM

目的研究丙泊酚靶控输注用于老年患者的群体药效学。方法32例择期下腹部开腹手术的患者,麻醉诱导和维持均用TCI丙泊酚(血浆浓度为3μg.mL-1),以反相高效液相色谱-荧光法测定丙泊酚的血浆浓度。用NONMEM软件对老年患者丙泊酚群体药效学进行分析。结果以BIS值作为药效学指标,用左旋滞后回线药代动力学/药效学(PK/PD)链式模型,建立血药浓度与药效间的定量关系。结论中国人老年患者的Keo和EC50分别为0.13min-1,3.77μg.mL-1。

Objective To investigate the pharmacodynamics of propofol administered by target -controlled infusion （TCI） in Chinese elderly patients. Methods Thirty- two ASA Ⅰ - Ⅱpatients, undergoing selective lower abdominal operation were studied. Propofol was administered by TCI with Marsh parameter. The plasma concentration of propofol ana- lyzed by reversed - phase HPLC with fluorescence detection. Pharmaeo- kinetic and pharmaeodynamie modeling was performed using NONMEM soft ware. Results Taken BIS as clinical index,the quantitative relation- ship between blood concentration and pharmaeodynamies was analyzed by PK/PD link model with left - hysteresis loop. Conclusion Keo of elder patients in China was 0.13 min^-1, EC59 was 3. 77μg·mL^-1