摘要
观察哈萨克族传统发酵乳酪的乳清(简称乳酪乳清)对实验性动脉粥样硬化大鼠的作用。健康SD大鼠40只随机分为5组:正常组(n=8),髙脂模型组(n=8),阳性对照组(n=8)及给药组(n=16)。通过高脂饮食4周及内皮损伤建立动脉粥样硬化大鼠模型,给予哈萨克族传统发酵乳酪的乳清(大、小剂量组)及阳性对照药辛伐他汀3周后,分别测定肝指数(肝重/体重)、血脂、肝脂、C-反应蛋白等指标,并对大鼠冠状动脉,主动脉病理形态学进行观察。结果表明,乳酪乳清0.5mg/100g和1mg/100g组及辛伐他汀组(0.5mg/100g)降低动脉粥样硬化大鼠血清胆固醇(TC)分别为30.9%(P<0.01)及19%(P<0.05)。低密度脂蛋白胆固醇(LDL-C)分别降低17.3%(P<0.05)及31.3%(P<0.01)。模型组与给药组和辛伐他组相比,C反应蛋白显著降低(P<0.01)。病理切片结果表明,乳酪乳清能明显减轻大鼠动脉粥样硬化性损伤。结论:乳酪乳清0.5mg/100g组和1mg/100g组均具有调血脂作用,提示乳酪乳清具有显著抗大鼠实验性动脉粥样硬化作用。
Object To study the effect of chess whey which is a kind of Kazakh medicine on experimental atherosclerotic formation in rats Methods：40 rats randomly divided into 5 groups ：normal group,control group, model group and dosage groups. By using high fat diet and injury of endothelial cells establish a arteriosclerosis in rats. after that comparatively observe plasma, blood vessel actives and C-reaction protein Results： Serum total cholesterol, low density lipoprotein cholesterol, triglyceride in plasma decreased compared with those of model group Conclusion chess whey had antiatherogenic properties.
出处
《中国乳品工业》
CAS
北大核心
2007年第7期17-19,共3页
China Dairy Industry
