非洛地平缓释片在兔体内药物动力学和生物利用度比较

Pharmacokinetics and Bioavailability of Different Felodipine Extended-release Tablets in Rabbits

目的比较几种国产非洛地平缓释片在兔体内的药物动力学和生物利用度。方法用高效液相色谱法测定兔口服药物后血浆中的药物浓度,以普通非洛地平片作为参照,计算其药物动力学和生物利用度。结果在1.0～80μg.L-1范围内,非洛地平血浆药物浓度与色谱峰高呈良好的线性关系。单剂量兔血浆中非洛地平缓释片动力学参数不同产品存在差异,相对于普通制剂的生物利用度分别为179%、162%、122%。结论不同产品非洛地平缓释片药物动力学和生物利用度存在差别。

Aim To compare pharmacokinetics and bioavailability of different felodipine extended-release tablets. Methods Drug concentration in rabbit plasma following a single oral dose of 5 mg felodipine extended-release tablets was determined by high performance liquid chromatography method. With the general felodipine tablets as the control, pharmacokinetics and bioavailability were calculated and compared. Results Good linear relationship between felodipine concentration within ranges of 1.0 - 80μg·L^-1 in plasma and the peak-high was obtained. Pharmacokintic parameters were remarkably different for different felodipine extended-release tablets in rabbits, and bioavailability as against the general felodipine tablets were 179%, 162% and 122% respectively. Conclusions Pharmacokinetics and bioavailability were different for different felodipine extended-release tablets in rabbits.