摘要
目的研究高渗氯化钠右旋糖酐70注射液(Hypertonic saline dextran70 injection,HSD)是否具有血管刺激性、溶血性和过敏性作用。方法对中试产品进行了血管刺激性实验、全身过敏实验和溶血实验。结果HSD对血管没有明显的刺激作用;不引起豚鼠的过敏反应;不引起溶血和红细胞凝集作用。结论制剂的安全性得到确证。
Aim To evaluate safety of HSD. Methods Vascular stimulation, hemolysis, and hypersensitivity experiments were used to test the semi-works product. Results Serious stimulation such as denaturation and necrosis was not seen in rabbits＇ ear rim auricular vein after being given HSD. Allergic reaction did not occur in guineapigs. In vitro, HSD didn＇ t cause hemolysis. Conclusion The pharmaceutical safety of HSD was confirmed.
出处
《解放军药学学报》
CAS
2007年第4期289-291,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
首都特色临床医学技术发展研究课题
No.Y0905001040131
军队"十五"指令性课题
No.010L43
