清肾颗粒对腺嘌呤所致慢性肾功能衰竭大鼠血清甲状旁腺素的影响

Experimental study of Qingshen granule on the level of serum PTH in rats with chronic renal failure

目的观察清肾颗粒对慢性肾功能衰竭大鼠血清甲状旁腺素水平的干预作用。方法将腺嘌呤摄入量按每日300 mg.kg-1体重给予,制作慢性肾功能衰竭动物模型。用清肾颗粒(每ml含生药0.5 g)治疗,用保肾康(6 g.L-1)作对照。检测大鼠血清甲状旁腺素、肌酐、尿素氮和24 h尿蛋白定量及肾脏病理改变。结果造模各组大鼠上述指标和正常组相比明显增加(P<0.001)。治疗后上述指标和模型组相比明显减少(P<0.001)。结论清肾颗粒可显著降低CRF大鼠血清上述指标,其效果优于保肾康。

Aim To observe the level of serum parathyroid hormone（PTH） in rats with chronic renal failure（CRF） and the curative efficacy of Qingshen granule（QSG）.Methods The model rats of CRF were induced by adenine（300 mg·kg^-1） for 3 weeks,then treated respectively with Qingshen granule（0.5×10^3 g·L^-1） and Baoshenkang tabs（6 g·L^-1） for 4 weeks.The serum levels of PTH,serum creatinin（SCr）,blood urea nitrogen（BUN） and 24 hours urine protein（24 hUpro） of the rats and the pathologic changes of the kidneys of the rats were observed.Results The serum levels of PTH,SCr,BUN and 24 h Upro of the CRF rats of every model group increase much significantly compared with those of the normal rats（P〈0.001）.The serum levels of PTH,SCr,BUN and 24 h Upro also significantly decrease after 4 weeks treatment compared with the model group（P〈0.001）.Conclusion Qingshen granule may decrease the serum levels of PTH,SCr,BUN and 24 hUpro of CRF rats,and the effect of it is better than that of Baoshenkang tabs.