河南省食管癌高发区食管癌组织SCCA1蛋白的表达

The Expression of SCCA1 in Esophageal Squamous Cell Carcinoma(SCC) in High-Incidence Area of Esophageal Cancer in Henan Province

目的探讨河南食管癌高发区居民食管癌组织中SCCA1蛋白表达的变化特征及其意义。方法采用常规组织病理学方法和免疫组织化学(ABC)法,检测河南食管癌高发区居民食管癌组织中SCCA1蛋白的表达状况。结果在30例食管癌组织SCCA1蛋白表达阳性17例(17/30,57%);淋巴结转移阳性组SCCA1免疫组化阳性组(13/22,59%)高于阴性组(4/8,50%),但无相关性(P>0.05);与细胞分化关系:高分化组SCCA1阳性表达(6/9,66%)高于中、低分化组(11/17,65%;0/4,0%),差异明显(P<0.05);与TNM分期关系:SCCA1阳性表达与Ⅰ期(2/3,66%)、Ⅱa期(2/3,66%)、Ⅱb期(3/6,50%)、Ⅲ期(6/12,50%)、Ⅳ期(4/6,66%)均无相关性(P>0.05)。在30例癌旁配对正常组织中未发现SCCA1蛋白表达,与癌组织中SCCA1蛋白表达差异明显(P<0.05)。结论SCCA1蛋白阳性表达与食管癌的细胞分化程度密切相关,SCCA1蛋白阳性表达可作为食管癌患者预后判断的标志之一。

Objective To characterize the expression and significance of SCCA1 with esophageal squamous cell carcinoma （SCC） in high-incidence area of esophageal cancer in Henan province. Methods SCCA1 protein of 30 patients with esophageal squamous cell carcinolna was detected by immunohistochemical staining （ABC）. Results SCCA1 positive immunoreactivity was detected in 17/30 （57%） distributed mainly in cytoplasm and scarcely in nucleus and there was no expression in 13/30 （43%） cases. The positive expression of SCCA1 in patients with lymph node metastasis （13/22, 59% ） was higher than that in those without lymph node meiastasis （4/8, 50% ）, but the difference was not significant （P 〉 0.05）. The positive SCCA1 expression in advanced SCC （6/9, 66% ） was obviously higher than that in moderately differentiated （11/17, 65% ） and poorly differentiated （0/4, 0% ）, the difference was significant （P 〈0.05）. The positive expression of SCCA1 showed no correlation with TNM staging （P〉0. 05）. None of SCCA1 protein expression was detected in normal tissues （0/30, 0% ） and the difference was significant between tumor and normal tissues （P 〈0. 05）. Conclusions SCCA1 protein expression in SCC tissues was correlated well with well differentiated SCC （P 〈 0. 05） , This suggested that SCCA1 may be one of prognostic indicators for SCC.