摘要
目的探讨CD147及基质金属蛋白酶-2(MMP-2)在胃癌中表达特点及其生物学行为关系。方法应用免疫组织化学S-P法检测58例胃癌组织及20例正常胃黏膜组织中CD147和MMP-2的表达情况。结果CD147及MMP-2在胃癌组中的阳性表达率分别为77.6%及82.8%,均高于正常胃黏膜组(P<0.01);两者的阳性表达均与胃癌的浸润深度、临床分期及淋巴结转移有关,与分化程度无明显关联;胃癌中CD147及MMP-2的表达具有相关性(P<0.01)。结论胃癌组织中CD147和MMP-2的高表达,可以作为胃癌生物学行为的客观参考指标。
Objective To investigate the relationship between the expressions of CD147 and matrix metalloproteinase-2（MMP-2） and the biology behaviors in gastric cancer. Methods CD147 and MMP-2 expressions were examined by immunohistochemical S-P staining method in 56 cases with gastric cancer and 20 cases with normal gastric tissues. Results The expression rates of CD147 and MMP-2 in gastric carcinoma tissues were 77.6% and 82.8% , respectively, which were significantly higher than those in normal gastric mucosa （P 〈 0.01 ）. The expressions of CD147 and MMP-2 were closely correlated with clinical phases, depth of invasion and metastasis of lymph nodes, but no association was observed with pathological grades. There was a significant correlation between the expressions of CD147 and MMP-2 in gastric carcinoma （P 〈 0.01 ）. Conclusions The overexpressions of CD147 and MMP-2 may be used as one of the objective marks to estimate the behaviors of gastric carcinoma.
出处
《肿瘤基础与临床》
2007年第1期21-23,共3页
journal of basic and clinical oncology
