三种抗病毒治疗方法对慢性乙型肝炎患者生活质量的影响

Assessment on life quality of patients with chronic hepatitis B after three types of antiviral treatment

目的:探讨不同治疗方法治疗的慢性乙型病毒性肝炎,对生活质量的影响.方法:选择143例慢性乙型肝炎患者,随即分为序贯治疗组(拉米夫定+干扰素α2b,n= 56)、拉米夫定组(n=60)、干扰素组(n=27).应用标准化的量表(SF36中文版)评定法,对全部调查对象进行健康状况调查问卷.每名治疗对象于治疗前、治疗结束、随访结束分别接受评定3次.结果:三种不同的治疗方法对慢性乙型肝炎患者的生活质量影响不明显,同一治疗方法在治疗前、治疗后、随访后患者的生活质量也无显著性差异;治疗结束和随访结束,不同病毒载量的患者其生活质量亦没有显著性差异.结论:慢性乙型肝炎患者的生活质量与不同的抗病毒治疗方法无关,临床医师应根据患者的病情选择合理、有效的抗病毒方案并辅以积极的心理干预以最终提高患者生活质量.

AIM： To assess the life quality of patients with chronic hepatitis B after different approaches to anfiviral treatment. METHODS： A total of 143 patients were randomly divided into group A, B and C, received lamivudine plus interferon-α2b sequential therapy, lamivudine and interferon-α2b therapy,respectively. The life quality of the 143 patients with chronic hepatitis B was assessed by the quality of life questionnaire （SF-36 in Chinese）. The laboratory data and marks of questionnaires were compared before and after the antiviral treatments. The marks of the following-up period were also considered. RESULTS： The SF-36 marks of patients with chronic hepatitis B were not significantly different between the 3 types of antiviral treatments. There were no significant differences between the marks of life quality before and after the same treatment. The life quality of patients with different virus loads showed no marked differences, either, at the end of antiviral treatment and following up. CONCLUSION： The life quality of patients with chronic hepatitis B is not associated with the different antiviral approaches. It is essential that a reasonable and available antiviral approach combined with the positive psychological treatment should be used to improve the patients＇ life quality.