苔色酸酯的合成及抗真菌作用的研究

Synthesis and anti-fungal activity of orsellinic esters

目的：合成出一系列苔色酸酯，并测试其抗真菌作用。方法：以石花为原料，经丙酮提取得到红粉苔酸，用半合成方法，制备苔色酸酯。以试管内药液稀释法，考察苔色酸酯的抗真菌作用。结果：合成出了7个苔色酸酯，其结构经元素分析、IR和ESI—MS等表征；其中5个对常见的浅层致病真菌如絮状表皮癣菌等的最低抑菌浓度范围在20～150μg·mL^-1，4个对深层真菌如申克孢子丝菌等的最低抑菌浓度在40～300μg·mL^-1。结论：苔色酸酯对9种致病真菌抑菌作用显著，且效果均优于3，5-二羟基甲苯。

Objective ：To synthesize a series of orsellinic esters, then to investigate their anti-fungal activity. Methods：Parmelia tinctorum Despr. was taken as starting material, after extracting with acetone, lecanoric acid was obtained. Then by semi-synthesis with lecanoric acid and alcohols, to prepare orsellinic esters. The tube dilution method was used to examine anti-fungal effect of orsellinic esters. Resuits：Seven orsellinic esters were synthesized, their structures was confirmed by elemental analysis, IR, ESI-MS etc. The MIC of five orsellinic esters on superficial pathogenic fungals ranged from 20 - 150μg·mL^-1, while four on deep pathogenic fungals ranged from 40 - 300μg·mL^-1. Conclusion： The experimental study indicated orsellinic esters had obviously anti-fungal effect on nine pathogenic fungals, and which was better than orcinol.