摘要
目的研究辛伐他汀作为激活物对骨生成的促进作用。方法72只大鼠随机分为3组。实验组大鼠左侧颞骨骨膜下袋内放置辛伐他汀与Bio-Oss骨粉复合物,对照组单纯填入Bio-Oss骨粉。观察大鼠术区情况和生活状态,于术后4、8、12周分别处死大鼠,进行组织学观察、新骨总面积测量、成骨细胞计数和红外光谱分析,观察骨增量变化。结果空白组4、8、12周颞骨厚度均无明显变化。4周,骨粉或复合物相对稳定,未见骨痂生长。8、12周,实验组与对照组对比明显。新骨面积和成骨细胞数目实验组多于对照组,实验组新骨生长活跃且速度较快;红外光谱分析,骨痂内无机成分高于对照组。结论辛伐他汀在大鼠颞骨表面植骨过程中,有促进新骨生成作用。
Objective To study the stimulation effect of stallns （Simvastatin） as a activation on bone formation. Methods Seventy-two SD rats were randomly divided into three groups： group A with untreated rats; group B with Bio-oss alone implanted on temporal bone; group C with Simvastafin-bio-Oss complex implanted on temporal bone. The rats were sacrificed after 4, 8 and 12 weeks and the bone formation was observed. Results While no differences was observed in the first 4 weeks, after 8 and 12 weeks, the bone formation in group C was better in quality, demonstrated by infrared spectrophotometry, and more osteoblasts and new bone area were found in group C. Conclusion Simvastatin-Bio-Oss complex can improve bone formation on rats temporal bone.
出处
《广东牙病防治》
2007年第8期342-344,共3页
Journal of Dental Prevention and Treatment
基金
广东省科技三项经费计划项目(2006B19901006)
关键词
辛伐他汀
成骨作用
骨生成
Simvastatln
Osteogenesis
Bone formation
