摘要
以一定重力致家兔侧股骨中下1／3处粉碎性骨折造成创伤性休克模型，连续监测血压4h．采用薄层层析及无机磷定量法测定肺表面活性物质（PS）的主要功能成分磷脂酰胆碱（PC）和总磷脂（TPL）含量．观察到创伤后4h末．血压及肺组织匀浆PC含量明显低于生理盐水（NS）对照组（P＜0．01），TPL含量亦降低，但不如PC显著（P＜0．05）．创伤前给予山莨菪碱(654—2），能防止血压降低和PS减少．结果提示，PS减少是创伤性休克时重要的病理生理变化；654—2能减轻或在一定程度上防止休克的发生和发展．
The left femur of the middle and the 10wer 1/3 comminuted fracture in rabbits was produced by means ofgravity,which resulted in traumatic shock. Lung homogenate content of phosphatidylcholine(PC) and totalphospholipid (TPL) were measured by thinlayer chromatography and quantitative analysis of inorganic phos-phorus. The results showed that the content of PC and TPL were decreased. Administrating 6542 be foreshock and at 2 hours or administrating it at 2 hours only could both prevent the decrease of PC and TPL con-tent in lung homongenate.
出处
《职业卫生与病伤》
1997年第1期7-9,共3页
Occupational Health and Damage
