大剂量维生素C和地塞米松治疗猫急性颅脑伤的对照实验研究

Experimental Study on Large-Dose Vitamin C and Large-Dose Dexamethasone in the Treatment of Head Injuried Cats

目的：探讨大剂量维生素Ｃ对急性颅脑伤的治疗效果。方法：以自由落体法致猫脑挫伤后分组静脉滴注维生素Ｃ（２００ｍｇ／ｋｇ）和地塞米松（５ｍｇ／ｋｇ），测定血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ含量的变化，对挫伤区脑组织进行光镜和电镜观察。结果：维生素Ｃ治疗组动物脑创伤区病理改变明显好于颅脑伤组，脑含水量、颅内压以及血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ的含量均显著低于颅脑伤组，与大剂量地塞米松组相比，脑含水量亦显著降低。结论：大剂量维生素Ｃ治疗急性颅脑伤与大剂量地塞米松治疗效果相当，而且在降低脑水肿方面优于地塞米松。

Objective:Large-dose vitamin C in treating head injuried were performed.Methods:The animals were rendomly divided into four groups,and the cerebral contusion were produced by the same method of freely falling body.A dose of 2oomg/kg of vitamin C and 5 mg/kg of dexamethasone were respectively injected intravenously at the moment and 6 hours after injury.The neuropetides were measured in CSF and serum.The traumatized cerebral tissues were studied under light microscope and electron microscope.Results:Brain water content,neuropeptides in CSF and serum were significantly lower in vitamin C group than in head-injuried group.Conclusions:Large-dose vitamin C could reduce second brain damage and brain edema after head injury,and could be used clinically.