急性脑血管意外者超氧化物歧化酶及丙二醛变化研究

A study on SOD and MDA of acute cerebrovascular diseases in the elderly patients.

目的通过对６４例老年急性脑血管意外患者发病初期及病后２周血清超氧化物歧化酶（ＳＯＤ）活性及丙二醛（ＭＤＡ）含量的研究，可进一步了解脑血管疾病与氧自由基的关系。方法分析我院１９９５年至１９９６年４月收治的急性脑血管意外患者６４例（脑出血、脑梗塞各３２例），在其发病的初期（３天内）与病后２周分别抽血检查了ＳＯＤ及ＭＤＡ含量。并选择了６０例健康老人作对照组。结果脑出血、脑梗塞组患者发病初期ＳＯＤ活性明显低于对照组，而ＭＤＡ含量明显增高，以脑出血组更为显著，２组比较Ｐ＜０．００１。２周后２组病人的两项指标均有恢复，但Ｐ值仍有显著差异，仅少数脑梗塞病人恢复至正常范围内。结论本研究证实急性脑血管意外患者在急性期血氧自由基产生增加，且病情危重程度与ＭＤＡ呈正相关。因此，临床上可根据上述两项值作为估计病情、判断预后及评价疗效的一项参考指标。也为临床抗氧化治疗提供了参考依据。

Objective The paper studied the activity of SOD and the content of MDA in 64 elderly patients with apoplexy,in order to obtain a better understanding of the relation between cerebrovascular diseases and oxygen free radical. Methods Serum SOD and MDA were studied in 64 subjects with apoplexy(cerebral hemorrhage∶32 cases,cerebral infarction∶32 cases)and in 60 age matched healthy controls.Serum were obtained in the early stage(within three days)and two weeks after attack. Results It was found that SOD activity in the patients was significantly lower than that in the control group and the content of MDA in the patients,especially in the group of cerebral hemorrhage,was significantly higher than that in the control group( P <0 001).Both parameters in the patients were resumed two weeks later,but still showed significant difference with the control group yet.The values of only a few cerbral infarction cases were restored. Conclutions Our study confirmed that the content of oxygen free radical increased in elderly patients with apoplexy and there was a positive relation betwee the patient’s condition and MDA.One could estimate the state of illness,judge the prognosis and apprasise the curative effect by the values of SOD and MDA.