止痛酊的制备及质量控制

The Preparation and Quality Control of Dicentrine

目的：制定止痛酊的制备工艺及质量标准。方法：用渗漉提取法提取有效成分,制备酊剂,采用TLC法对处方中白芍和红花药材进行定性鉴别;采用HPLC法对栀子中栀子苷进行含量测定。结果：制得的酊剂,在TLC色谱中均能明显地检出白芍和红花;HPLC法测得栀子苷在0-2.860μg浓度范围内,线性关系良好,平均回收率为100.07%,RSD为1.25%。结论：本制剂工艺可行,质控方法简便、准确、专属性强,能有效控制止痛酊的质量。

Objective： To formulate the preparation technology and quality control of Dicentrine. Methods： Extracting the active component by percolate pheresis and preparing tinctura, making qualitative appreciation of paeoniae alba and carthami of prescription by thin - layer - chromatography methods, making assay of jasminoidin of cape jusmine fruit by high performance liquid chromatography. Results： Paeoniae alba and carthami caal be detected obviously in preparing tinctura by thin - layer - chromatography methods, the density of jasminoidin is between 0 - 2.8601a,g by high performance liquid chromatography,linear correlation is fine, average recovery is 100.07%, RSD is 1.25%. Conclusion： The technology of praeparatum is fine, quality control method is convient, accurate and specific, which can control effectively the quality of Dicentrine.