摘要
研究一种用离子导入的方法使布洛芬透皮吸收进入体内的给药系统。设计和制备布洛芬透皮吸收溶液；研究其稳定性并采用自行设计的便携式离子导入装置对免进行布洛芬经皮吸收的观察。结果：布洛芬离子导入溶液在兔体内的药动学参数为：K＝D．4206h-1t＝1．804h，Ka＝2．2648h－1，t＝0．365htp＝1．041h,Cm＝32．41μg·ml-1，AUC＝120．06hmgL-1。结论：布洛芬离子导入经友给药系统可取代传统的口服给药方式，且无后者之缺点。
objective:To study an ioophoretic method in order to enhance the transdermal absorption of ibuprofen.Method:A best prescription of ibuprofen transdermal solution was prepared and its stabilty was Studied. A portable ionPhoretic apparatus was designed and developed. Using this apparatus, transdermal absorption of ibuprofen was observed in rabbits.Results:In rabbits the pharmacokinetic parameters of ibuprofen trasdermal solution were: k =0. 4206h-1, t = 1. 894h, Ka = 2. 2648h-1, t(a) = 0. 365h, tp= 1 .041h, Cm = 32. 41μg/ml, AUC = 120. 06mg h/LConclusion:The transdermal ionphoretic ibuprofen delivery system could replace traditional 'per os'mode as administration dosage form, this delivery system could not cause side effect of ibuprofen.
出处
《天津药学》
1997年第1期8-15,共8页
Tianjin Pharmacy
