尿毒症病人血浆中分子物质对大鼠心功能的影响

EFFECT OF MIDDLE MOLECULAR SUBSTANCES FROM THE PLASMA OF URAEMIA PATIENTS ON RATS’ CARDIAC FUNCTION

将０．３ｍｍ塑料管沿颈总动脉插入大鼠左心室，采集的信号经换能器输入微电脑，应用ＣＡＲＤＩＯ软件，记录心功能的多项指标，经尾静脉注射从尿毒症病人血浆中分离出的中分子物质（ＭｉｄｄｌｅＭｏｌｅｃｕｌａｒＳｕｂｓｔａｎｃｅｓＭＭＳ），观察多项心功能指标的变化。结果表明：注射ＭＭＳ后，可明显抑制心率，室内压峰值降低；且室内压达峰值的时间延长；注射生理盐水后，上述指标的变化无意义。提示ＭＭＳ对心功能有一定抑制作用。

With a plastic cannula (0.33mm in diameter)intubated into the left ventricle of rats along common carotid artery,the indexes of cardiac function were sampled via a transducer and then transferred to a microcomputer to be recorded with CARDIO software.Middle moleculalr substances(MMS)separated from the plasma of uraemia patients were injected into rats’tail veins,and its effect on cardiac function was observed.The result showed that the injection of MMS could inhibit the cardiac rate obviously,lower the peak of intraventricular pressure and prolong the time length of intraventricular pressure reaching its peak,while,injection of normal saline didn’t cause statistically significant changes of the indexes above mentioned.The result indicated that MMS could inhibit rats’cardiac frnction