在急性白血病治疗中粒细胞集落刺激因子的作用

The role of rhG-CSF in the therapy of leukemia(Abstract)

本文观察了急性白血病患者化疗后骨髓抑制期，中性粒细胞绝对值＜０．５×１０９／Ｌ时，基因重组粒细胞集落刺激因子（ｒｈＧ－ＣＳＦ）的作用情况。可见：注射ｒｈＧ－ＣＳＦ２～３μｇ／ｋｇ／ｄ，共７天，外周血白细胞数于第三天开始逐渐上升，第８天均值达４．２１×１０９／ｌ，中性粒细胞低于０．５×１０９／Ｌ时间缩短，感染发生率降低，感染程度减轻，易于控制，各项指标均优于未用ｒｈＧ－ｃｓｆ组，提示ｒｈＧ－ＣＳＦ对急性白血病是一个具重要作用的细胞因子。

$$$$ Lian Shimei, et al The Affiliated Hospital of Dalian Medical University Abstract The article observed the role of rhG-CSF on the patients with acute leukemia during the inhibitive period of bone marrow and the absolute value of neutrophil was less than 0 5×10 9/L after chemotherapy.the patients were given rhG-CSF2-3ug/kg body weight/day for 7 days.the nuber of peripheral leukocyte began gradually increased from third days and it could reach 4 21×10 9/L at the eighth days.The time during which the number of neutrophils was less than 0 5×10 9/L shortened.The rate of infection decreased and its degree became slighter.It was easy to cure the infection.All indexes in the group treated with rhG-CSF were better than control.It suggest that rhG-CSF was an inportant cellular factor in acute leukemia.