甘氨双唑钠配合三维适形放疗治疗老年肺癌的近期疗效观察

Observations on short-term uherapeutic effects of glycididazole combined with three-dimensional conformal radiotherapy for elderly patients with lung cancer

目的探讨甘氨双唑钠对老年人肺癌三维立体适形放射治疗(3D-CRT)的放射增敏作用和安全性。方法经病理证实的老年肺癌病人27例,均采用甘氨双唑钠增敏并配合三维立体适形放射治疗技术进行治疗。甘氨双唑钠剂量为800mg/m2,用100ml生理盐水稀释溶解,于30min内滴注完,3h内完成放疗;3D-CRT采用6MeV直线加速器,单次剂量5·0～6·0Gy,3次/周,总剂量40～42Gy/3～4周,应用剂量体积直方图(DVH)评估治疗计划,确保周围正常组织及敏感组织的受量在许可范围内。结果CR17例(63%),PR10例(37%),CR+PR达到100%,未见明显的毒副反应。结论甘氨双唑钠具有明显的放射增敏作用,配合3D-CRT治疗老年人肺癌可取得较好的临床疗效。

Objective To explore the role of glycididazole （CMNa） in enhancing radiosensitivity to three-dimensional conformal radiotherapy （3D-CRT） and its safety in elderly patients with lung cancer. Methods Twenty-seven elderly patients with lung cancer, which had been confirmed by pathological examination, were treated with radiosensitizer glycididazole （CMNa） and 3D-CRT. Diluted with 100ml saline solution, 800mg/m^2 glycididazole （CMNa） was intravenously injected within 30 minutes, and 3D-CRT was performed within 3 hours. 3D-CRT was composed of 6MeV liner accelerator at a dose of 5. 0-6. 0 Gy/fraction for 3 fractions/week with a total dosage of 40 -42Gy/3-4weeks. Treatment plan was evaluated by dose volume histogram （DVH） to ensure peripheral normal tissue and sensitive tissue to receive the dose within a permitted extent. Results Seventeen cases （63%） showed complete responses （CR）, and 10 cases （37%） showed partial responses （PR）, theretore the total response rate was 100% （27/27）. No patients suffered from obvious adverse effects. Conclusions With significant ability to enhance radiosensitivity, glycididazole combined with 3D-CRT afford an effective treatment for elderly patients with lung cancer.