摘要
背景：他汀类药物可降低低密度脂蛋白胆固醇（LDL-C）水平并延缓冠状动脉粥样硬化的进展。但目前尚无资料描述他汀类药物所致高密度脂蛋白胆固醇（HDL-C）变化与疾病进展之间的关系。目的：研究LDL-C及HDL-C水平变化与粥样斑块负荷之间的关系。设计、机构和参与者：对4项前瞻性随机试验（1999-2005年分别在美国、北美、欧洲和澳大利亚进行）的原始资料进行事后分析。这些试验共纳入1455例经血管造影确诊冠心病的患者，患者均在接受他汀类药物治疗18个月或24个月时进行系列血管内超声检查。所有研究的超声分析均在同一个中心实验室进行。
Context： Statins reduce low-density lipoprotein cholesterol （LDL-C） levels and slow progression of coronary atherosclerosis. However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein Cholesterol（HDL-C） and disease progression. Objective： To investigate the relationship between changes in LDL-C and HDL-C levels and atheroma burden. Design, Setting, and Patients： Post-hoc analysis combining raw data from 4 prospective randomized trials（performed in the United States, North America, Europe, and Australia between 1999 and 2005）, in which 1455 patients with angiographic coronary disease underwent serial intravascular uhrasonography while receiving statin treatment for 18 months or for 24 months. Ultrasound analysis was performed in the same core laboratory for all of the studies.
