摘要
与裸金属支架相比，药物洗脱支架（DES）内皮化过程延迟。晚期血管壁不良重构和炎症也归因于药物／聚合物涂层。近期的注册资料表明，与以往的临床试验经验相比，日常临床实践中DES血栓形成的风险增加，这已引起对DES长期安全性的关注。作者拟在接受冠状动脉DES治疗的大样本患者队列中确定1年期间内支架血栓形成的发生率、病因学、治疗和临床后果。纳入2003年4月至2004年6月间在梅约医疗中心（明尼苏达州罗切斯特）接受至少1枚DES置入的连续患者（n=1213）。
Drug-eluting stents（DESs） exhibit delayed endothelializa- tion compared with bare metal stents. Adverse late vessel wall remodeling and inflammation have also been attributed to the drug/polymer coating. Recent registry data suggesting increased risk of DES thrombosis in routine clinical practice compared with previous clinical trial experience has led to concerns regarding long-term safety of these devices. We sought to determine the frequency, etiology, and clinical outcomes of stent thrombosis over 1 year in a large patient cohort treated with coronary DESs. Consecutive patients（n = 1, 213） who received ≥11 DES between April 2003 and June 2004 at the Mayo Clinic（Rochester, Minnesota） were identified. Medical records pertaining to all deaths, major adverse cardiac events, and/or repeat coronary angiograms after DES placement were evaluated to identify cases of stent thrombosis.
