摘要
内皮素-1参与动脉粥样硬化和缺血性心脏病的发生。尚无基于人群的研究验证内皮素-1和冠心病（CHD）之间的关系。作者对961例老年男性和女性进行了横断面分析。CHD定义为心肌梗死病史、冠状动脉手术、心绞痛或心电图上主要的Q波异常。对已知的危险因素和动脉粥样硬化指标进行校正后，检测了内皮素-1和CHD的相关性。共有248例女性和156例男性患有CHD。男性与女性之间内皮素-1的中位水平相似，而CHD患者的水平高于无CHD者的（3．3ng／L铘3．1ng／L，P〈0．001）。对年龄、吸烟、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、高血压、糖尿病、饮酒习惯、锻炼、阿司匹林、降脂药物治疗和激素疗法使用情况进行校正后，内皮素-1与CHD之间的相关性在女性中（OR3．02，95％CI1．43～6．37）强于男性中（OR1．82，95％C10．74～4．51）。
Endothelin-1 has been implicated in atherosclerotic and ischemic heart disease. No population-based studies have examined the association of endothelin-1 with coronary heart disease（CHD） We performed a cross-sectional analysis of 961 older women and men. CHD was defined as a history of myocardial infarction, coronary surgery, angi- na, or major Q-wa＇~e abnormality on electrocardiography. We examined the association of endothelin-1 with CHD after adjusting for known risk factors and atherosclerosis measures. A total of 248 women and 156 men had CHD. Median endothelin-1 levels were similar by gender and higher among those with versus those without CHD（3.3 vs 3.1 pg/ml, p 〈 0. 001） . After adjusting for age, smoking, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, hypertension, diabetes, alcohol use, exercise, aspirin, cholesterol-lowering medication, and hormone therapy use, endothelin-1 had a stronger association with CHD in women（odds ratio [OR] 3.02, 95% confidence interval 1.43 to 6.37） than in men（OR 1.82, 95% confidence interval 0. 74 to 4. 51）.
