摘要
背景：此项观察性研究旨在探讨术前使用或未使用他汀类药物治疗的搭桥手术患者的术后房颤（AF）发生率。方法和结果：研究对象由362例连续患者组成（267例术前使用他汀类药物，95例未使用）。他汀类药物治疗组中糖尿病更为常见（P=0．03）。两组之间其他人口统计学及手术操作变量相似（所有P〉0．05）。与未用他汀类药物组比较，使用他汀类药物组的术后AF较少，持续时间也更短（分别为P=0．03和P=0．0001）。Ka．plan-Meier分析表明，他汀类药物对AF发生风险具有保护作用（P=0．01）。结论：搭桥手术前的他汀类药物治疗可降低术后AF的发生率并缩短其持续时间。
Backround： The aim of the present observational study is to search the incidence of postoperative atrial fibrillation （AF） in patients with or without preoperative statin treatment. Methods and Results： The population consisted of 362 consecutive patients（267 on and 95 not on statin） . Dia- betes mellitus was more frequent in statin group（p = 0. 03）. Other demographic and procedural variables were similar in the both groups （All p 〉 0. 05）. Postoperative AF was less frequent and its duration was shorter in statin group com- pared to non-statin group（p =0. 03 and 0. 0001, respectively） . The Kaplan-Meier analysis showed the protective effect of statins against the risk of developing AF（p = 0. 01） . Conclusion： Statin treatment before the by-pass surgery decreases the incidence and shortens the duration of postoperative AF.
