摘要
先前的研究表明，在一些CAD患者中尽管左室功能尚保存，但其脑利钠肽（BNP）水平仍升高，然而此现象的潜在机制尚未被完全阐明。主动脉硬化在CAD患者中较明显，且随CAD严重程度增加而加重，因此考虑存在以下可能：随着主动脉硬化的加重，CAD患者的BNP水平也会升高。本研究检测134例CAD患者的BNP水平和肱动脉-踝动脉脉搏波速度（baPwV），评估二者间的关系。基于BNP四分位水平对患者进行分组，以确定高BNP水平患者的特征。BNP处于最高四分位水平的患者的baPWV明显高于其他四分位水平患者。
Previous studies demonstrated that the B-type natriuretic peptide （BNP） level is high in some patients with coronary artery disease（CAD） despite a preserved left ventricular function, although the mechanism underlying this increase in patients with CAD has not been fully elucidated. Be- cause aortic stiffness is greater in patients with CAD and increases with CAD severity, there is a possibility that an increased aortic stiffness in turn increases the elevation of the BNP level in patients with CAD. In this study, we measured BNP level and brachial-ankle pulse wave velocity （baPWV） in 134 patients with CAD, and evaluated the relationship between BNP and baPWV.
