摘要
背景：肥胖可改变一些分子的血管内皮细胞蛋白表达（VECPE），从而影响对动脉粥样硬化的易感性。方法和结果：研究对象为无其他临床疾病、肥胖程度不同的108例男女性受试者（体重指数18．4～36．7kg／m^2；总体脂肪5．8～55．0kg；腰围63．0～122．9em），用定量免疫荧光法检测其血管内皮细胞。所有3种肥胖状况的表达方式均与氧化酶亚单位NAD（P）H氧化酶-p47[部分相关系数（rpart）=0．22～0．24，所有P〈0．05]和抗氧化酶过氧化氢酶（rpart=0．71～0．75，所有P〈0．001）的VECPE呈正相关。
BACKGROUND - Obesity may alter vascular endothelial cell protein expression（VECPE） of molecules that influence susceptibility to atherosclerosis. METHODS AND RESULTS - Quantitative immunofluorescence was performed on vascular endothelial cells collected from 108 men and women free of clinical disease who varied widely in adiposity（body mass index 18.4 to 36. 7 kg/m^2; total body fat 5.8 to 55.0 kg; waist circumference： 63.0 to 122. 9 cm） . All 3 expressions of adiposity were positively associated with VECPE of the oxidant enzyme subunit NAD （P）H oxidase-p47（part correlation coefficient [rpart] 0. 22 to 0. 24, all P 〈 0. 05） and the antioxidant enzyme catalase （rpart =0. 71 to 0. 75, all P 〈0. 001）. Total body fat was positively associated with VECPE of nitrotyrosine（rpart =0. 36, P =0. 003）, a marker of protein oxidation,
