摘要
目的：已有文献表明，高水平的微量蛋白尿与严重的动脉粥样硬化相关。在此项前瞻性人群研究中，作者验证了低范围内的尿白蛋白／肌酐比值（ACR）是否与动脉粥样硬化的发生及发展相关。方法和结果：研究共入选4037例非糖尿病受试者，其中2203例在基线时无粥样硬化斑块，而1834例基线时已有粥样硬化斑块。所有受试者接受颈动脉超声检查，并检测了ACR、纤维蛋白原、单核细胞、白细胞计数以及已明确的心血管危险因素。7年后，进行了新的超声检查。在基线时无粥样硬化斑块的受试者中，有884例在随访期间至少出现了一个斑块。
Aims： High levels of microalbuminuria have been associated with severe atherosclerosis. In this prospective, population-based study, we examined whether urinary albumin-to-creatinine-ratios（ACR） in the lower range were associated with the initiation and progression of atherosclerosis. Methods and results： Carotid uhrasonography and measurements of ACR, fibrinogen, monocytes, white cell count, and well-established cardiovascular risk factors were performed in 4037 non-diabetic subjects, 2203 without, and 1834 with pre-existing plaques at baseline. After 7 years newuhrasound measurements were performed. In subjects without pre-existing plaques, 884 had developed at least one plaque during follow-up. Baseline ACR was significantly related to the area of the novel plaques（P for linear trend = 0. 009 over the baseline ACR quartiles, after multiple adjustments） .
