摘要
目的：近来，炎症、止血及血液流变学标记物作为冠心病和卒中的危险因素越来越多地受到重视。然而，这些标记物在外周动脉疾病（PAD）中的作用尚不明确，而且其中的一些指标（包括促炎细胞因子白细胞介素-6；IL-6）尚未在之前的前瞻性流行病学研究中探讨过。方法和结果：在爱丁堡动脉研究中，作者在一般人群中研究了PAD的发生情况，同时评价了17种可能作为新发PAD预测因素的血液标记物。在基线（1987年）时，共入选1519例年龄在55～74岁、无PAD的男性及女性。17年后，208例受试者发生了有症状的PAD。
Aims： Recently, markers of inflammation, haemostasis, and blood rheology have received much attention as risk factors for coronary heart disease and stroke. However, their role in peripheral arterial disease（PAD） is not well established and some of them, including the pro-inflammatory cytokine interleukin-6（IL-6）, have not been examined before in prospective epidemiological studies. Methods and results： In the Edinburgh Artery Study, we studied the development of PAD in the general population and evaluated 17 potential blood markers as predictors of incident PAD. At baseline（1987）, 1519 men and women free of PAD aged 55 -74 were recruited. After 17 years, 208 subjects had deveioped symptomatic PAD. In analysis adjusied for cardiovascular risk factors and baseline cardiovascular disease（CVD）, only C-reactive protein, fibrinogen, lipoprotein（a）, and haematocrit [hazard ratio（95% CI） corresponding to an increase equal to the inter-tertile range 1.30（1.08, 1.56）. 1.16（1.05.1.17）, 1.22（1.04, 1.44）, 1.22（1.08, 1.38）] were signifieantly（P 〈 0.01） associated with PAD. However,
