摘要
目的：二尖瓣反流（MR）是急性心肌梗死患者的独立危险因素。用来自VALIANT（缬沙坦在急性心肌梗死中的应用）超声研究的数据来分析基线MR与左室（LV）大小、形状和功能之间的关系，并评估基线MR及MR进展和心血管（CV）预后间的关系。方法和结果：研究了496例在心肌梗死（MI）后中位期5d接受超声心动图检查的合并心力衰竭（HF）和（或）收缩功能障碍的MI后患者。分别在基线、MI后1个月和MI后20个月时检测MR严重程度（通过反流喷射面积／左房面积比值定量），将该指标与LV大小、形状、功能和临床预后进行相关性分析。
Aims： Mitral regurgitation（MR） confers independent risk in patients with acute myocardial infarction. We utilized data from the VALsartan In Acute myocardial iNfarcTion echo study to relate baseline MR to left ventricular（LV） size, shape, and function, and to assess the relationship between baseline MR and progression of MR and cardiovascular（CV） outcomes. Methods and results： We studied 496 patients with heart failure（HF） and/or systolic dysfunction after MI who underwent echocardiography at a median of 5 days after MI. MR severity, quantified as the regurgitant jet area/left atrial area ratio, was assessed at baseline, one and 20 months post-MI and related to LV size, shape, function, and clinical outcomes. Increased MR at baseline was associated with larger LV end-diastolic and end-systolic volumes, increased sphericity index, and reduced ejection fraction（P trend 〈0. 001）
