摘要
目的：通过测定平均血小板体积（MPV）和血浆可溶性P-选择素（SP-sel）水平来评价奈比洛尔对高血压患者血小板激活的影响，并与服用美托洛尔的患者进行了比较。方法：共有80例新近诊断为高血压1级的患者被纳入此项随机化、盲法、前瞻性研究。72例患者完成了研究。经过基线评估后，随机分配患者接受5mg／d奈比洛尔（n=37，男性20例）或100mg／d美托洛尔（n=35，男性18例），共治疗6个月。分别在治疗前后，测定患者的血压、心率、血脂、血糖、SP-sel水平、血小板计数和MPV。
Objectives： We evaluated the effects of nebivolol on platelet activation in hypertensive patients by measuring mean platelet volume （MPV） and plasma soluble P-selectin （SP-sel） levels and compared with those of the patients taking metoprolol. Materials and methods： Eighty newly diagnosed hypertensive patients in grade 1 hypertension were enrolled in this prospective, blinded randomized study. Seventy two patients completed the study. After baseline assessment, each patient was randomly allocated to 5 mg daily dose of nebivolol（n = 37, 20 male）or 100 mg daily dose of metoprolol（n = 35, 18 male） and treated for 6 months. Blood pressure, heart rate, lipid profile, plasma glucose, sP-selectin levels, platelet counts and MPV were measured before and after treatment.
