摘要
目的：本前瞻性随机研究旨在调查主动脉狭窄（AS）患者中，主动脉瓣设计和患者一人工瓣膜不匹配（PPM）对机械或生物主动脉瓣置换术（AVR）后冠状动脉血流储备（CFR）的影响。背景：CFR可能是AS患者AVR后长期存活的一个重要参数。CFR减少可以导致心血管事件和死亡率的增加。方法：48例行AVR的患者在术前、术后5d和随访6个月时进行磁共振检查。测定冠状动脉血流，并在随访6个月时测定CFR。拟行机械瓣AVR的患者被随机分为侧倾碟瓣（n=12）或双叶瓣组（n=12）。
Objectives： This prospective-randomized study investigated the effect of aortic valve design and patient-prosthesis mismatch （PPM） on coronary flow reserve （CFR） after mechanical or biological aortic valve replacement（AVR） in patients with aortic stenosis（AS） . Background： Coronary flow reserve may be an important parameter of long-term survival after AVR in patients with AS. Reduced CFR may contribute to more cardiovascular events and greater rates of mortality. Methods： A total of 48 patients undergoing AVR underwent magnetic resonance imaging for the measurement of coronary flow preoperatively, 5 days postoperatively, and at 6-month follow-up with measurement of CFR. Pa- tients scheduled for mechanical AVR were randomized to a tilting disc or bileaflet prosthesis（n = 12 in each group） .
